269 Piotin -100

COMPOSITION :Each 1 gm contains:

Biotin      0.220 mg

Excipient up 1 gm

PACKAGING: 5 Kg

PIOTIN-100 is an oral feed supplement rich with Biotin for horses, it is a water-soluble vitamin and plays an important role for:

• Hoof health:

which the Biotin helps generate long-chain fatty acids, which are critical for building the cell membranes in the hoof's outer layers. These fatty acids also contribute to the elasticity and moisture retention of the hoof, preventing cracks.

Also the Biotin work as a cofactor in synthesizing proteins necessary for keratin formation, the producing of a dense, hard keratin, helps to tougher and regeneration of hoof tissue, which is critical for maintaining hoof strength over time.

• Hair, Mane, and Tail Quality:

Biotin function in hair involves keratin synthesis. Keratinocytes in hair follicles rely on biotin to produce strong keratin filaments, which form the main structural component of hair.

Biotin helps the lipid barrier that protects hair follicles from environmental stress is strengthened by biotin-mediated fatty acid production. These fatty acids form a hydrophobic layer on the hair shaft, reducing moisture loss and preventing breakage.

Biotin supports cellular turnover and the natural hair growth cycle (anagen, catagen, and telogen phases). Horses deficient in biotin may experience disrupted growth cycles, leading to excessive shedding or slower hair regrowth.

• Metabolism and Energy Production:

When the horses require glucose for intense physical activity, biotin helps convert non-carbohydrate sources into glucose via gluconeogenesis in the liver, where biotin acts as a cofactor for pyruvate carboxylase, which converts pyruvate into oxaloacetate. This pathway provides an alternative energy source for the horse during times of fasting or strenuous exercise.

Also, Biotin facilitates the oxidation of fatty acids, allowing the horse to use fats for long-term energy storage and mobilization when needed especially during extended periods of low-intensity exercise.

Biotin helps with the breakdown of branched-chain amino acids (leucine, isoleucine, and valine), which are essential for muscle recovery and energy during exercise. These amino acids provide an energy source for muscle tissue and contribute to the horse's endurance and muscle mass maintenance.

• Skin Health:

Biotin aids in the rapid turnover of skin cells by ensuring that cells are properly nourished and equipped with the necessary building blocks. This is particularly important in horses subjected to environmental stressors (sun exposure, dust, and insects).

Biotin helps the skin to produce an adequate lipid by facilitates the synthesis of sphingolipids and ceramides, which maintain moisture in the skin, protect against infections, and reduce dryness.

Biotin promotes faster cell repair and growth when a horse experiences skin abrasions or cuts and helps in regeneration of healthy skin tissue. This effect is due to its role in collagen production and protein synthesis, key elements in tissue healing.

• Nervous System and Neurological Support:

Biotin contributes to myelinogenesis by supporting the synthesis of fatty acids and other lipids that make up this protective layer around neurons.

Biotin is involved in the production of neurotransmitters by supporting glucose metabolism. Nerve cells, especially in the central nervous system, rely on glucose as their primary energy source. Biotin ensures that neurons can metabolize glucose efficiently, which is crucial for maintaining the horse’s neuromuscular coordination and overall neurological health.

Biotin is necessary for nerve function and muscular control, it is Prevent of neurological such as ataxia (uncoordinated movement) in horses.

• Hoof Capsule Integrity and Shock Absorption:

Biotin enhances the hoof’s ability to absorb shock and withstand the physical stress from riding or training. This is particularly important for performance horses, where repetitive concussion on hard surfaces can lead to hoof soreness and cracks. Biotin helps distribute pressure more evenly across the hoof, reducing the likelihood of injuries.

• Immune Function:

Biotin plays a role in the proper functioning of immune cells, particularly macrophages and T-cells, which defend against infections. By supporting cellular energy production and fatty acid synthesis, biotin ensures that immune cells have the energy to mount a response to pathogens. This is crucial for horses exposed to environmental stressors, parasites, or pathogens, ensuring their immune system stays robust.

• Hormonal and Endocrine Support:

Biotin has been shown to influence insulin sensitivity and glucose metabolism, which can be important in managing equine metabolic syndrome (EMS) and preventing insulin resistance in horses. It helps regulate glucose uptake in cells, allowing for more stable blood sugar levels and potentially reducing the risk of insulin-related disorders, such as laminitis in predisposed horses.

PIOTIN-100 can be administered by mixing the daily dose in the feed or by grain preferably rolled or ground. To facilitate proper adhesion of PIOTIN-100 to the ration, slightly moisten the grain with water or liquid supplement.

Horses: 68 gm per day.

Ponies: 34 gm per day.

WITHDRAWAL PERIOD: None

STORAGE: Store in cool and dry place don’t exceed 30 ºC